Abstract
11β p-hydroxysteroid dehydrogenase type 1( 11β-HSD1 ) , a glucocorticoid ( GC ) regulatory enzyme,is involved in the regulation of GC from level to activity in the central nervous system. 11β-HSD1 mediates the conversion of cortisone to cortisol, amyplifying the action of local GC. The higher level of intra-cellular GC in brain results in the lesion of the hippocampus and the impairment of cognition. Inhibition of 11β-HSD1 or peroxisome proliferator-activated receptor ( PPAR) -γ agonists can improve the cognitive dysfunction associated with diseases such as Alzheimer disease (AD) and amnestic mild cognitive impairment, by inhibiting or reducing the expression of 11β-HSD1. Key words: 11β-HSD1; Cognition; Hippocampus; Inhibitor of 11β-HSD1; PPAR-γ agonists
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