Pterostilbene–Nicotinamide Cocrystal: A Case Report of Single Cocrystals Grown from Melt Microdroplets

Abstract

Screening and single-crystal growth of cocrystals is a time-consuming process, typically performed by solution crystallization. Here we reported a case that a single pterostilbene–nicotinamide cocrystal was efficiently cultivated from melt within 30 min, resulting in successful structure elucidation. This new cocrystal was discovered from melts and can be prepared on a gram scale within 10 min by simply seeding melts at 80 °C. This work demonstrates the possibility of growing single cocrystal from the melts and highlights the high efficiency of melt crystallization in research of pterostilbene–nicotinamide cocrystals.