Abstract
Among all cancer types, lung cancer has already become the leading cause of cancer-related death around the world. The molecular mechanism understanding this development is still needed to be improved to treat lung cancer. Stathmin (STMN1) was initially identified as a cytoplasmic protein phosphorylated responding to cell signal and controlled cell physiological processes. The dysregulation of STMN1 is found in various kinds of tumors. However, the molecular mechanism of STMN1 regulating lung cancer is still unclear. Here, we found that STMN1 was overexpressed in lung cancer tissues and associated with worse survival rates of lung cancer patients. Inhibition of STMN1 suppressed lung cancer cell growth, migration and invasion, and promoted drug sensitivity. Moreover, PTEN loss promoted STMN1 expression via PI3K/AKT pathway. PTEN loss ameliorated the inhibition of cell growth, migration and invasion, and drug sensitivity induced by STMN1 knockdown in lung cancer. The high expression of STMN1 was negatively correlated with the low expression of PTEN in lung cancer specimens. Overall, our work demonstrated that PTEN regulated the oncogenic function of STMN1 in lung cancer.
Highlights
Among all cancer types, lung cancer has already become the leading cause of cancer-related death around the world[1]
We found that the expression of STMN1 in lung cancer was higher than normal tissues (Fig. 1a)
The expression of STMN1 was evaluated in our data by real time PCR, and the results showed that STMN1 expression was up-regulated compared with normal tissues (Fig. 1b)
Summary
Lung cancer has already become the leading cause of cancer-related death around the world[1]. Following a large number of reports to investigate the lung cancer pathologic progression, the molecular mechanism understanding this development is still needed to be improved[5,6]. Given the oncogene function of STMN1, STMN1 is called as oncoprotein 1813. Increased expression of STMN1 benefitted anchorage-independent cancer cell growth by cJun. the molecular mechanism of STMN1 regulating lung cancer is still unclear. PTEN conducts by negatively regulating PTEN/PI3K/Akt signaling pathway that regulates multiple cellular functions such as cell growth, apoptosis and migration. We investigated the function of STMN1 gene in lung cancer and might molecular mechanism underlying lung cancer progression. We found that overexpression of STMN1 changed lung cancer cell growth, migration, invasion and drug sensitivity. PTEN loss in lung cancer regulated the expression and function of STMN1
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