Abstract
In the present study, we synthesized a Schiff base (L 1 ) derived from L-phenylalanine with furfuraldehyde and its Pt(II) complex ([Pt(L 1 )(L 2 )]: [Pt(N-(furfuralidene)phenylalanine)(8-hydroxyquinoline)]) in the presence of 8-hydroxyquinoline (L 2 ). The chemical structures of the synthesized Schiff base and Pt(II) complex were characterized using ESI-MS, UV–Visible, FT-IR, 1H NMR, 13C NMR, and powder-XRD spectroscopy. The surface morphologies and elemental composition were determined by SEM and EDX. Thermal analysis was performed with TG-DTA. Mole ratio of Meyer and Job methods were used for the composition of complexes. According to these methods, the ratio [Pt 2+ ] : [L 1 +L 2 ] was found to be 1 : 1. In addition, the antimicrobial activities of L 1 and the complex showed that the compounds have significant antibacterial and antifungal properties. They also show important cytotoxic effects against the growth of mouse embryo fibroblasts (MEF) and human prostate adenocarcinoma (Du145) cancer cells. L 1 , L 2 , and the Pt(II) complex also displayed effective antioxidant activity.
Highlights
Schiff bases are an important class of ligands that help to elucidate the mechanisms of various reactions in biological and chemical systems due to the presence of an imine group in their structures
Vanadium complexes of Schiff bases derived from o-vanillin/L-valine [17] and L-serine/2-hydroxy-1-naphthaldehyde in the presence of 1,10-phenanthroline [18] were synthesized and the binding properties studied
According to our antimicrobial activity results, while the obtained complex was effective against S. aureus, L. monocytogenes, and C. albicans at 6.25 μg/mL concentrations, L1 showed moderate antibacterial activity against S. aureus, L. monocytogenes, and C. albicans at 12.5, 12.5, and 6.25 μg/mL concentrations, respectively
Summary
Schiff bases are an important class of ligands that help to elucidate the mechanisms of various reactions in biological and chemical systems due to the presence of an imine group in their structures. Schiff bases containing nitrogen and oxygen donor atoms can be obtained by the condensation of various aldehydes and amines Due to their structural and functional properties, Schiff bases derived from aldehydes and amino acids with transition metal ions have various applications in chemical, biological, and medical fields [1,2,3,4,5]. These compounds have antimicrobial and antifungal activities against certain bacteria and fungal strains, respectively [6,7,8,9]. Metal complexes of Schiff bases derived from amino acids play a significant role in the investigation of DNA-binding and bovine serum albumin (BSA)-binding properties.
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