Abstract
Lipoteichoic acid (LTA) isolated from Staphylococcus aureus was found to exert a synergistic effect with calf serum to enhance DNA synthesis and growth of mouse embryo fibroblasts. LTA alone had no effect on DNA synthesis or cell multiplication. Mild base hydrolysis of LTA, which separates the molecule into its hydrophilic and hydrophobic moieties, completely destroyed its biological activity in this regard. Results are presented which suggest that LTA may enhance serum-induced DNA synthesis through interaction with cell surface components. The data indicate that LTA may prove to be a useful tool with which to probe cell membrane parameters involved in the regulation of cell proliferation.
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