Psychometric validation of the Korean PROMIS-29 Profile v2.1 among patients with chronic pulmonary diseases in Korea

Abstract

Patients with chronic pulmonary diseases (CPD) commonly experience breathlessness, dyspnea, fatigue, depression and reduced social functioning. However, the traditional patient-reported outcome measurement which focused on symptoms, had a limited scope of applicability. This study aimed to validate the Korean version of Patient-Reported Outcome Measurement Information System 29 Profile V2.1 (K- PROMIS-29 V2.1) in a sample of patients with CPD. Participants were recruited at the respiratory disease outpatient clinics of the Samsung Medical Center in Seoul, South Korea from September to October 2018. Participants completed a survey questionnaire including K-PROMIS-29 V2.1 and the Short Form Health Survey version-2.0 (SF-36v2). Exploratory and confirmatory factor analysis (CFA) and Pearson’s correlations were used for evaluating reliability and validity of the K-PROMIS-29 V2.1. The mean age of the study participants was 62.8, and 188 (89%) completed the entire questionnaire. The Cronbach’s alpha coefficients of 7 sub-domains in K-PROMIS-29 V2.1 ranged from 0.77 to 0.96, indicating satisfactory internal consistency. In CFA, the goodness-of-fit indices were high (CFI = 0.90 and SRMR = 0.06). Moderate correlations were found between comparable subscales of the K-PROMIS-29 V2.1 and subscales of the SF-36v2 (r = 0.55–0.70). The K-PROMIS-29 V2.1 is a reliable and valid measure for assessing a broad range of health-related quality-of-life domains in patients with CPD.