P115. Evaluation of PROMIS physical function in anterior cervical discectomy and fusion

Abstract

BACKGROUND CONTEXT As Patient-Reported Outcomes Measurement Information System (PROMIS) becomes increasingly utilized, it is important to assess its validity procedure-specific populations. PURPOSE This study aims to evaluate the utility of PROMIS physical function (PF) domain as compared to legacy measures of patient reported outcomes (PROs) among patients undergoing an anterior cervical discectomy and fusion (ACDF). STUDY DESIGN/SETTING Retrospective. PATIENT SAMPLE A total of 57 patients undergoing a primary, 1-3 level ACDF. OUTCOME MEASURES PROMIS PF, NDI, VAS Neck and Arm, SF-12. METHODS Patients undergoing a primary, 1-3 level ACDF were retrospectively identified from a prospectively-maintained surgical registry. PROMIS PF and legacy PRO scores were obtained at preoperative and 6-week, 12-week, and 6-month postoperative visits. Legacy PROs included Neck Disability Index (NDI), Short Form-12 (SF-12) physical composite, Visual Analog Scale (VAS) neck pain and VAS arm pain. Postoperative improvements in PROs were assessed using paired t-tests. Correlations between PROMIS and legacy PROs were tested using Pearson correlation coefficient with strength of association interpreted as follows: |r|=0.1-0.3, weak; |r|=0.3-0.5, moderate; |r|=0.5-1.0, strong. RESULTS A total of 57 ACDF patients were included in this analysis. PROMIS PF scores significantly improved at 12 weeks and 6 months postoperatively, but not at 6 weeks. NDI, VAS neck pain, and VAS arm pain scores demonstrated significant improvement at all postoperative timepoints. SF-12 scores exhibited significant improvement at the 6-month follow up visit. Significant correlations between PROMIS PF and NDI and SF-12 were identified at all preoperative and postoperative timepoints. PROMIS PF exhibited strong correlations with VAS neck pain at postoperative timepoints and a moderate correlation preoperatively. CONCLUSIONS Patients undergoing a primary 1-3 level ACDF experience significant improvements in PROMIS PF scores at 12-week and 6-month postoperative visits, but not at 6-weeks. PROMIS PF exhibits strong correlations to NDI and SF-12 at all preoperative and postoperative timepoints. These results suggest that PROMIS PF accurately measures physical function and may be used in lieu of legacy physical function instruments for patients undergoing ACDF. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.