PSS19 HEALTH-RELATED QUALITY OF LIFE, WORK PRODUCTIVITY, AND ASSOCIATED FINANCIAL BURDEN AMONG ADULTS WITH PSORIASIS

Abstract

To evaluate the relationship between health-related quality of Life (HRQoL) and work productivity (absenteeism and presenteeism), and estimate the financial burden associated with psoriasis (PsO) among adult patients in the US and five European countries (5EU). Adelphi Psoriasis Disease Specific Program data from 2015 were analyzed. PsO HRQoL was evaluated using the Dermatology Quality of Life Index (DLQI) total score (0-30) and band scores (0-1= no effect; 2-5=small; 6-10=moderate; >10=large effect). Absenteeism (percentage of work hours missed due to PsO) and presenteeism (percentage of work hours restricted due to PsO) were calculated from the Work Productivity and Activities Index (WPAI) and translated into indirect costs (2015 US dollars) using the human capital approach. Univariate and multivariable analyses were conducted controlling for patient demographics and disease characteristics. Overall, 936 patients (29.6% US and 70.4% 5EU) completed the WPAI and DLQI questionnaires; 37.2% were female; mean age was 42.4 years (SD=10.2). DLQI total mean score was 5.1 (range 0-30;SD=5.1); DLQI band scores among patients indicated 33% had no, 27% had small, 25% had moderate, and 15% had large effect of PsO on HRQoL. For every 1-point increase in DLQI total score, work productivity loss increased by 0.46% for absenteeism and 2.07% for presenteeism, which corresponded to mean annual indirect costs per patient of $1,155 and $6,307, respectively. Compared to those reporting PsO had no effect on HRQoL, absenteeism and presenteeism progressively increased by DLQI band score for mild [1.4%,6.3%], moderate [1.8%,16.8%] and large effect [4.9%,29.4%], respectively. This corresponds to mean annual indirect costs for absenteeism and presenteeism for mild [$1,184;$4,927], moderate [$1,269;$9,591] and large effect [$2,372; $13,289], respectively. Lower HRQoL among adults with PsO is associated with reduced work productivity and higher economic burden, with greatest consequences among those reporting PsO had a large effect on HRQoL.