Abstract
A microporous polyurethane lattice has been used to line 8 and 11 mm. diameter knitfed Dacron grafts which were implanted into the canine infrarenal aorta and thoracic inferior vena cava. Similar grafts made from Dacron velour were used as control experiments. The surface of the lattice grafts were rapidly covered and healed into a stable collagen surface both in the aorta and vena cava. The majority of the velour grafts showed incomplete healing and significant thrombus deposition. Superior results obtained with the lattice grafts were thought to be related to the more complete incorporation of the pseudointimal layer into the lattice matrix. This produced a firm attachment of the initial fibrin layer which rapidly was transformed into collagen. The speed of coverage and the rapid transformation of the pseudointima into a stable collagen matrix probably accounts for the thrombus-resistant nature of this material and may explain its superiority to velour.
Published Version
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