PS4 - 20. Alterations in the M-CSF gene result in hepatic lipid accumulation in spite of reduced hepatic inflammation

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Low-grade inflammation and steatosis are strongly associated with non-alcoholic fatty liver disease (NAFLD), the hepatic component of the metabolic syndrome. Macrophage colony stimulating factor (M-CSF) plays a key role in inflammation through its effects on macrophage development and function. Although macrophages have been proposed to play an active role in obesity, the role of macrophages in the development of NAFLD is still a matter of debate.