Abstract
Abstract Background The verrucous carcinoma of the esophagus is a rare, very slowly growing and uncommonly metastasizing locally progressive and highly differentiated squamous cell carcinoma. The genesis of the tumor is not completely clarified but often associated with human papilloma virus or chemical toxic exposure of the mucosa. On endoscopy it appears as an exophytic, villous, with whitish hyperkeratosis, endosonographically pretending a uT3N + situation. Patients often present with dysphagia and unspecific reflux symptoms. Often several biopsies of the tumor are needed to make the diagnosis, because few routinely taken standard biopsies often show unspecific inflammation or mycotic Infections. However, the carcinoma is subjacent. Diseases on rare occasions often need extensive diagnostics, therefore we want to cal in mind the verrucous carcinoma of the esophagus. Methods Small case series in a single center patient collective. Results From 2010 to 2017, 55 patients underwent an esophageal resection. In two patients (3,6%) a verrucous carcinoma was diagnosed. That is far more often than expected. Conclusion In patients with dysphagia and macroscopic villous structure on endoscopy, further samples should be taken despite benign primary histology and a reference pathologist should be involved. Disclosure All authors have declared no conflicts of interest.
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