PS-C34-13: LATE NIGHT EATING OR CIRCADIAN DISRUPTION COULD BE MORE DANGEROUS THAN OUR THINK FOR PATIENTS OF DIABETES WITH HYPERTENSION

Abstract

Background: Our bodies function optimally when we align our eating & sleeping patterns with our circadian rhythms, the innate 24-hour cycles that tell our bodies when to wake up, when to eat and when to fall asleep. Chronically disrupting this rhythm by eating late night meals & sleep could be a recipe for Hypertension, CVD, and metabolic trouble. Aim & Objective: The aim of this study is to investigate whether there was a relationship between morningness(MC) (110n) intermediate(IC) (100n) & eveningness chronotype(EC) (35n) in T2DM. Methods: A total of 245 subjects age 18 to 60 years were recruited in Clinical OPD of General Medicine, KGMU. We have tested FBG & PP level, lipid profile HbA1c, Insulin, Leptin and Cortisol level, 48 hours ABPM. Result: When we compared these 3 groups, Significant Different parameters found in FBG (P = 0.01) Postprandial (P = 0.03) HbA1c (P = 0.001) TG (P = 0.0001), Total Cholesterol (P = 0.01) & VLDL (P = 0.005). It also shows the complete inversion of the cortisol level (0.003). Insulin, IL-1 beta & IL-6 also show significant change in late night eating T2DM Patients. Systolic / Diastolic readings of ABPM shows significant change between MC and IC (0.005) but not b/w EC & IC (0.007). And for reliability of sleep by actigraphy shows MC (6:15 + 1:35) & EC (8:18 + 1:23) take complete sleep but IC total sleep hours (5:10 + 1:05) are very less. Disruption of Rev Erb & Ror alpha gene expression is also a risk factor for Cardio metabolic Diseases in T2DM Patients. Conclusion: Eveniningness & Intermediate Type Patients are more likely to have late night eaters & are associated with greater risk of Metabolic Disorders like Blood Pressure Variability, Dyslipidemia, T2DM & CVD.