Abstract
Objective: To investigate the characteristics, control rate, and factors affecting blood pressure (BP) control in treated hypertensive patients with obesity in Korea. Design and Method: The Korean hypertension registry (KorHR) is an on-going prospective nation-wide multicenter (15 teaching hospitals) cohort study since 2013. As of Jan 2016, the interim analysis of 1,318 consecutive subjects was performed to understand the baseline characteristics of the population. Obesity was defined as body mass index (BMI) ≥ 25 kg/m2). Results: Of all cohort patients, we selected 430 patients taking antihypertensive drug who have visited clinic more than once. Obesity hypertension (Ob-HT) group (232, 54%) was younger (54.9 ± 11.2 vs. 57.4 ± 11.2 year, p = 0.029) and fatter (28.1 ± 2.6 vs. 23.1 ± 1.5 kg/m2, p < 0.001), included more men (63.4% vs. 49.0%, p = 0.003) and dyslipidemia (60.3% vs. 47.5%, p = 0.009) and had the higher level of hemoglobin, hematocrit, glycated hemoglobin and uric acid than non-obese hypertension (nonOb-HT) group. Ob-HT was treated with more antihypertensive drugs (1.9 ± 0.7 vs. 1.7 ± 0.8, p = 0.007) usually in combination (69.4% vs. 53.0%, p = 0.001). There was no significant group difference regarding systolic and diastolic BP (130.9 ± 12.9 vs. 130.6 ± 14.9 mmHg; 79.7 ± 11.3 vs. 77.8 ± 10.4 mmHg) and BP control rates (73.6% vs. 70.4%). Among antihypertensive drugs, angiotensin receptor blocker was most frequently used (81.9%) in Ob-HT but calcium channel blocker (68.7%) in nonOb-HT. Although there was no significant difference in clinical characteristics between patients with controlled and uncontrolled BP in nonOb-HT group, uncontrolled BP patients in Ob-HT group were younger (50.5 ± 11.8 vs. 56.5 ± 10.6 year, p < 0.001) and heavier (79.4 ± 11.4 vs. 75.9 ± 11.2 kg, p = 0.032). Conclusions: Ob-HT group consisting of more than half of treated hypertension was younger and male gender was more prevalent in the group. Although the overall BP control rate was relatively high regardless of obesity, the younger and much heavier patients were associated with poor BP control in Ob-HT. Those patients need to be received more focus on the treatment.
Published Version
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