PS 05-71 CROSS-SECTIONAL RELATIONS OF PERIPHERAL BLOOD PRESSURE AND CENTRAL BLOOD PRESSURE ACCORD TO AGE; DATA FROM THE KOREAN REGISTRY OF TARGET ORGAN DAMAGES IN HYPERTENSION(KorHR)

Abstract

Objective: To determine the relationship between peripheral blood pressure (BP) parameters and central BP parameters accord to age. Design and Method: The Korean Registry of Target Organ Damages in Hypertension (KorHR) is a multi-centered prospective study which has enrolled 1318 essential hypertension patients without any cardiovascular diseases since March 2013. Among these patients, this study analyzed 417 patients whose central BP data were available. Central and peripheral BP parameters were evaluated in relation to age groups (young: 20–39 yrs, n = 113; middle: 40–59 yrs, n = 292; old: 60 or more yrs, n = 112). Results: Despite similar central systolic BP across the 3 categories (130.1 ± 18.7 vs. 130.5 ± 17 vs. 132.6 ± 17.5, p = 0.614), there were a significant decreasing trend of peripheral systolic BP with age (151.1 ± 21.4 vs. 145.8 ± 18.5 vs. 140.4 ± 21, p = 0.002). In multivariate regression analysis, peripheral systolic BP was an independent determinant of central systolic BP only in the old age category (age≥60 yrs; β = 0.387, p < 0.001). Peripheral diastolic BP was more powerful predictor of central systolic BP compared to peripheral systolic BP in the young (age 20–39 yrs; β = 0.356, p < 0.001) and the middle aged (40–59 yrs; β = 0.219, p < 0.001) patients. Brachial PWV was the only variable which predicted central systolic BP significantly across all the 3 age groups. Conclusions: Peripheral systolic BP could predict central systolic BP only in old aged hypertensive individuals whose PWV was faster than that of younger individuals. These data suggests that peripheral systolic BP might have a limited value for predicting central systolic BP in young and middle aged individuals due to less degree of arterial stiffness compared to old aged individual.