A0329 Left ventricular structure and function in relation to peripheral and central blood pressure in a general population

Abstract

Objectives: Central blood pressure (BP) is a predictor of target organ damage. No previous population study addressed the question to what extent central compared with peripheral is related to left ventricu-lar (LV) structure and function. Methods: In 577 Flemish recruited from the general population (47.8% women; mean age 50.5 years), we assessed the multivariable-adjusted associations of echocardiographic LV structure and systolic and diastolic LV function (Vivid7 Pro device; EchoPac software, version 4.0.4; GE Vingmed, Horten, Norway) with peripheral and central pressure, as recorded by radial applanation tonometry (SphygmoCor software, version 9.0). Association sizes were expressed per 1-SD increment in peripheral or central systolic/diastolic BP. Results: Peripheral compared with central systolic BP was 10.2 mm Hg higher (P < 0.0001), whereas dias-tolic BP was similar peripherally and centrally (P = 0.50). Associations were closer (P ≤ 0.020) with central than peripheral systolic BP for LV mass (+0.886 g/m2) and left atrial volume (+0.166 ml/m2) indexed to body surface area, peak A transmitral flow (+0.343 cm/s), peak e′ mitral annular movement (–0.219 cm/s) and the E/A ratio (–0.021). Associations were closer (P ≤ 0.038) with central than peripheral diastolic BP for left atrial volume index (+0.267 ml/m2), e′ (–0.104 cm/s) and E/e′ (+0.081). Ejection fraction and global longitudinal strain were similarly associated with central and peripheral systolic (P ≥ 0.62) and diastolic (P ≥ 0.18) BP. Conclusion: In asymptomatic people recruited from the general population, LV mass and atrial volume indexes and selected haemodynamic measurements reflecting diastolic LV function are slightly but significantly closer associated with central than peripheral BP.