PS 04-06 INFLAMMATION AND OXIDATIVE STRESS IN UNCOMPLICATED ARTERIAL HYPERTENSION

Abstract

Objective: Inflammation and oxidative stress are important determinants for target organ damage in arterial hypertension. The aim of the study was to evaluate inflammatory and oxidative markers in uncomplicated arterial hypertension. Design and Method: Study population included 114 (59 male, age 30–65 years) untreated hypertensive non-diabetic pts without associated clinical conditions. Plasma concentrations of malonic dialdehyde (MDA) and SH-groups were evaluated as oxidative stress markers. Serum concentrations of high sensitive CRP (hsCRP), TNF-α, interleukins (IL) 1β, 4 and 6 were measured. Spearman correlation analysis and stepwise regression model were used to assess association between oxidative stress, inflammatory markers, BP and traditional risk factors. Results: In 45% pts elevation at least of one pro-inflammatory cytokine was found. In 26% this elevation was accompanied by low anti-inflammatory ratio (IL4/IL6), in 18% - with high IL4/IL6. In 55% concentration of all pro-inflammatory cytokines was lower than median. In one third of patients low cytokines levels were observed together with low IL4/IL6, in 22% - with high IL4/IL6. Regression analysis revealed independent correlation of hsCRP and SH/MDA (ß = −0,61; р = 0,003); TNF-α and total cholesterol (ß = 0,61; р < 0,001), diastolic BP (ß = 0,35; р = 0,001); IL1ß and plasma renin activity (ß = 0,50; р < 0,001); IL6 and smoking (ß = 0,65; р = 0,002); IL4/IL6 and LDL (ß = −0,55; р < 0,001); MDA and HDL (ß = −0,87; р < 0,001), IL4/IL6 (ß = −0,41; р = 0,01). Conclusions: In untreated hypertensive non-diabetic middle-aged pts high levels of pro-inflammatory cytokines may coexist either with low or high anti-inflammatory ratio. Inflammatory and oxidative status are interrelated and determined by diastolic BP, smoking, dyslipidemia and renin-angiotensin system activity.