Abstract
Background: Chronic kidney disease (CKD), with its high prevalence, morbidity and mortality, is an important public health problem. The progression of CKD has been shown to result in inflammation and oxidative stress. For CKD hemodialysis (HD) is the most common RRT modality in India. Present study aimed to compare and evaluate the immune modality profile, oxidative marker and biochemical profile of pre and post dialysis chronic kidney disease patients. Material and method: The study included 40 CKD patients depending on inclusion and exclusion criteria, attending HAHC hospital, HIMSR, New Delhi, which were on hemodialysis. The mean age of the patient was 60±15 yrs. Patients undergoing dialysis thrice in a week for about 4 hrs per session at flow 250-300 ml/min. Inflammatory and oxidative stress markers were assessed pre and post dialysis during any one session of dialysis in chronic kidney disease patients. Result: There was significant decrease in inflammatory and oxidative stress markers after dialysis. There was also significant decrease in biochemical marker levels post dialysis. Conclusion: Hence, evident from this study improvement in inflammatory markers and renal function test after dialysis suggests that indeed haemodialysis is the most common and better treatment option for chronic kidney disease patients.
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