Abstract
The paper presents a review of research on the anticancerogenic activity of flavonoid compounds and their prenylated derivatives occurring in the propolis. In addition to the numerous biological and pharmacological properties of flavonoids, they also have a cytotoxic effect. The presented studies of flavonoids isolated from propolis fractions of various origins were carried out in vitro and in vivo against various human and animal cancer cell lines, e.g. HT-1080 human fibrosarcoma cells, A549 lung adenocarcinoma and Hela cervix, murine L5-26 colon carcinoma and B16-BL6 melanoma, and others. The obtained cytotoxic activity of flavonoid compounds and their prenylated derivatives as IC50 values was in the range of 3.4-10.0 μg/ml, while the ED50 values were in the range of 2.3-205.0 μg/ml. Flavonoids have a multidirectional effect on cancer cells: antioxidant, antiproliferative, blocking the cell cycle, inhibiting angiogenesis, inducing apoptosis, and inactivating carcinogens and reducing the resistance of anti-cancer drugs.
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