Abstract
Chronic itch (CI) is the most common symptom in dermatology. It is considered a great burden with a large impact on patients' quality of life, interfering with everyday activities. During the course of chronic kidney disease (CKD) many patients develop end-stage renal disease (ESRD)-associated CI (ESRDCI). Its pathogenesis is yet to be fully explained, but multiple mechanisms have been described, including, among others, dysregulation of calcium, phosphorus, parathyroid hormone and vitamin D axis, microinflammation, and accumulation of uremic toxins. The treatment consists of both topical and systemic therapy, but unfortunately it is usually difficult and unsatisfactory. Renal transplantation (KTx) as the best renal replacement therapy improves considerably the patient's life quality and decreases the mortality rate. However, its influence on CI has not been well described. In this review, we presented the available literature on the influence of KTx on ESRDCI and demonstrated the possible ways in which transplanted kidney could help patients suffering from CI.
Highlights
Chronic kidney disease (CKD) is a global health problem affecting 13.4% of the world population, while 10.6% of people suffer from advanced stage of the disease.[1]
We presented the available literature on the influence of KTx on end-stage renal disease-associated chronic itch (ESRDCI) and demonstrated the possible ways in which transplanted kidney could help patients suffering from Chronic itch (CI)
The recent study by Schricker et al shows that 12% of the renal transplant recipients (RTR) are diagnosed with CI.[6]
Summary
Chronic kidney disease (CKD) is a global health problem affecting 13.4% of the world population (stages 1–5), while 10.6% of people suffer from advanced stage of the disease (stages 3–5).[1]. Chronic kidney disease patients often suffer from higher cardiovascular risk and develop a series of complications such as hyperparathyroidism and bone disorders, anemia, and dyslipidemias.[3]. Another troublesome symptom for patients with advanced stages of CKD is end-stage renal disease-associated chronic itch (ESRDCI), known as a uremic itch. It was first described in 19324 and till today remains an important problem for both patients and the doctors; it decreases patients’ quality of life and poses a significant therapeutic challenge.
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