Abstract

The formation of persister cells are among the most important strategies employed by the bacterial population to get rid of antibiotic treatment and external stress. E. coli overproduces amphiphilic α-helical peptide TisB(toxic protein) in harmful conditions, which is localized into the inner membrane. Whenever bacteria are under stress, the persister cells help to equilibrate PH gradient, thereby Proton Motive Force (PMF) is eliminated across the membrane. This phenomenon leads to the depletion of ATP levels in the membrane, which results in the formation of biofilm and induces the state of temporary dormancy.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.