Abstract
The formation of persister cells are among the most important strategies employed by the bacterial population to get rid of antibiotic treatment and external stress. E. coli overproduces amphiphilic α-helical peptide TisB(toxic protein) in harmful conditions, which is localized into the inner membrane. Whenever bacteria are under stress, the persister cells help to equilibrate PH gradient, thereby Proton Motive Force (PMF) is eliminated across the membrane. This phenomenon leads to the depletion of ATP levels in the membrane, which results in the formation of biofilm and induces the state of temporary dormancy.
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