Abstract
Proton pump inhibitors (PPIs) are a group of drugs that work by inhibiting the K+/H+- adenosine triphosphatase (ATPase) system, also known as the proton pump, in the gastric parietal cell wall. They therefore efficiently reduce hydrochloric (HCl) acid secretion in the stomach. PPIs are used as the treatment of choice for gastro-oesophageal reflux disease, peptic ulcer disease, non-steroidal anti-inflammatory drugassociated ulcers, Helicobacter pylori eradication and excess acid secretion in Zollinger-Ellison syndrome. They are also used as a short term therapy to treat intermittent gastric acid reflux when antacids and H2 receptor antagonists have proven to be ineffective. Their use, however, must be monitored to prevent secondary disease such as Clostridium difficile-associated diarrhoea and rebound excess gastric acid secretion (irritable bowel syndrome).
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