Abstract
IntroductionAngioedema (AE) is a local swelling in the subcutaneous/submucosal tissue produced by a transient increase of vascular permeability. ClassificationIt is classified into histaminergic AE (H-AE) and bradykinergic AE (BK-AE). There is another type of AE were leukotrienes are involved together with histamine as the mediators, and it is related to the intake of nonsteroidal anti-inflammatory drugs (NSAID-AE). AE is also divided into hereditary forms (HAE) and acquired (AAE). Diagnostic protocolsWhen facing an AE case it is important to conduct an approximative diagnosis that allows to classify the AE as histaminergic or bradykinergic to apply the most appropriate treatment. H-AE is usually erythematosus, pruritic, and hot, can have associated urticaria and responds to treatment with H1 antihistamines. Conversely, BK-AE is not erythematous, itchy or hot, it is not associated to urticaria and does not respond to H1 antihistamines. This protocol presents some diagnostic algorithms for the emergency room or outpatient consultations.
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