Abstract
Immunocompromised patients are increasingly common in clinical practice. Many may present with fever and an abnormal liver profile for various reasons. Initially, the same causes as for immunocompetent patients should be ruled out. Special attention should be paid to viral reactivations, opportunistic infections, drug-induced liver toxicity, and ischemia- and tumor-related causes. The diagnostic approach includes a detailed case history, personal history specifying the cause of the immunosuppression, physical examination, blood tests with a liver profile, previous and current blood tests, and imaging tests. If a diagnosis is not reached, a liver biopsy may be necessary.
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