Abstract

IntroductionCorticosteroids have been considered the treatment of choice for induction of remission in patients with active Crohn's disease. However, a significant number of patients have an inadequate response or adverse events to these drugs. Therapeutic managementIn this setting, immunosuppressants, thiopurines and methotrexate, and biologic drugs, mainly anti-TNF, have achieved a long-term free steroid clinical remission. PrognosisIn addition, the early and combined use of these drugs has been associated with a better prognosis with lower rates of relapse, hospitalization and surgery.

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