Prothrombotic Coagulation Factors (PTCF) in Symptomatic Neonatal Cerebral Infarction (SNCI). What is their Role?

Abstract

Background: PtCFs have been associated with SNCI, but their relative risks is still unknown.Objective: To examine the extent to which single and combined PtCF influence the onset of SNCI.Methods: Prospective multicenter case-control study. Factor V (FV) G1691A mutation; Prothrombin (PT) G20210A variant; MTHFR T677T genotype; Antithrombin III (AT); Protein C; Protein S; Lipoprotein (Lp-a); Homocystein and anticardiolipin antibodies were investigated in 29 infant-mother pairs with SNCI and in 28 infant-mother control pairs.Results: Eight of 29 patients (28%) had at least 1 PtCF compared with 9/28(33%) controls. PtCF were found in 17(58%) mothers of infants with infarction and in 9(36%) of mothers of healthy infants (OR 2,1, 95%CI 0,7-6,4). At least 2 factors were found in 2 neonates; one SNIC patient and one healthy control. Two mothers of a SNIC patient and a control, respectively, had at least 2 factors. Table Table Full size table Conclusion: Our data indicate that PtCF do not appear to play a major role in SNCI.