Abstract
This chapter provides an introduction to proteomics and describes current applications of proteomic technologies in investigative and clinical settings. Mass spectrometry-based proteomics is emphasized as a technology for unbiased and targeted interrogation of complex protein mixtures. Technological advances now permit higher sensitivity and accuracy for detection and quantification of biomarkers. Perspectives on current and future applications of mass spectrometry-based proteomics are provided in the context of diagnostic laboratory testing.
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