Abstract
Abstract:There is a high burden of both diabetes and tuberculosis in China. Althoug both diabetes and tuberculosis have been the objects of intensive study the association between the two diseases is not fully understood. The aim of this study was to determine whether thetqualitative and quantitative differences in expression of some protein expression in plasma could be related to active pulmonary tuberculosis complicated with diabetes. Using two‐dimensional gel electrophoresis and mass spectrometry we analyzed expression of the proteins associated with active pulmonary tuberculosis complicated with diabetes. Results showed that under the baseline condition, the levels of a‐1 antitrypsin precursor, vitamin D‐binding protein precursor, CD5 antigen like precursor, clusterin precursor, apolipoprotein A‐I precursor, haptoglobin and fibrinogen g‐chain differed between patients with active pulmonary tuberculosis and active pulmonary tuberculosis complicated with diabetes. Western blott results confirmed differential expression of clusterin. These results suggest that active pulmonary tuberculosis complicated with diabetes may be associated with specific protein expression pattern in plasma. C‐terminal haptoglobin is a possible candidate protein of interest, which might be a link between active pulmonary tuberculosis and diabetes. The dynamics of protein expression during disease progression may improve our understanding of the pathogenesis of active pulmonary tuberculosis complicated with diabetes.Supported by NSFC‐81172662
Published Version
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