Abstract
Objective The current study investigated differential blood protein profiling between the H7N9-infected patient and healthy people so as to find a slice of crucial proteins concerning disease attack. Methods The plasma samples of the first Avian influenza A(H7N9) patient in Northern China were collected at onset phase and convalescent phase, and plasma of the patient’s father (uninfected) were collected at the same period. The protein profiles were identified by isobaric tagging for relative and absolute quantification through iTRAQ-based quantitative differential LC/MS/MS, and their functional annotations were analyzed by PANTHER and STRING tools. Results A total of 250 differentially expressed proteins related to the infection of Avian influenza A(H7N9) virus were identified, among which 159 were up-regulated and 91 were down regulated. These differentially expressed proteins were involved in 11 biological processes, as well as 7 molecular pathways. Conclusions There is a series of changes in the plasma proteins after Avian influenza A (H7N9) virus infection, which were involved in 7 molecular pathways. Key words: Avian influenza A virus of H7N9; Proteome; ITRAQ.
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