Abstract
Introduction The placenta is an important organ for the optimal growth and development of the embryo and fetus during pregnancy because of its major functions in the absorption of nutrients, excretion of waste products, and gas transfer [1,2]. Over the past several decades, placenta transport functions have been studied in the
Highlights
The placenta is an important organ for the optimal growth and development of the embryo and fetus during pregnancy because of its major functions in the absorption of nutrients, excretion of waste products, and gas transfer [1,2]
The number of proteins that were tested is very small compared to the thousands of plasma proteins as there have been no high throughput and comprehensive studies of protein crossing of the placenta
Some injury-related proteins in placenta without placental barrier damaged Tissue specific and subcellular locations of all proteins showing significant changes (p
Summary
To evaluate the in situ perfused placenta model and applicate it to investigate the protein transfer functions of the placenta, the rat placenta was perfused in situ and the proteome of the perfusate was analyzed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in the present study
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