Abstract
• Cellular Ca 2+ signaling is fine-tuned by a set of Ca 2+ sensitive protein to control a variety of biological functions. • The rhomboid intramembrane protease RHBDL2 can downregulate abnormal Ca 2+ entry via CRAC channels. • RHBDL2 is sensitive to elevations in intracellular Ca 2+ concentrations and the presence of a proline in the TM domain containing the rhomboid cleavage site. • The gain-of-function mutant Orai1 P245L linked to the stormorken syndrome is defective in RHBDL2 mediated cleavage.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
