Abstract
Single ribosomes and polysomes were isolated from guinea pig hair follicle tissue by sucrose density gradient centrifugation and characterized by electron microscopy. Single ribosomes are held together by ribonucleic acid to form polysomes in the follicle cell as indicated by the disaggregating effect of added ribonuclease. Furthermore, the ribosomal population incorporates labeled amino acids into protein and requires those factors necessary for protein synthesis in other systems. The effects of added inhibitors of protein synthesis as well as artificial mRNA on the incorporation activity of hair follicle tissue are discussed in respect to our present knowledge of keratin synthesis.
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