Abstract
This article provides an insight into protein structure classifications and how they can be used to analyze protein structure and sequence data. Different classifications are compared and discussed, together with the methods used to develop them. We give an overview of the current status of the protein structural universe using information from these classifications, considering both structural relatives and uncharacterised sequences predicted to belong to the structural families. We discuss how these classifications inform analyses into the evolution of protein structure, sequence, and function. The impact of AlphaFold2 data on the protein structure classification is highlighted.
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