Abstract

Sequence comparison has become a standard tool in the analysis of newly determined protein sequences. As the database of known sequence grows not only does the cost of database searching increase but so too does the demand for that service. These factors conflict directly with the desire to use the most sensi tive methods available. The use of massively parallel computers for database searching provides a solution to this problem and is helping in the development of new methods for both sequence and structure com parison.

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