Abstract
Biological macromolecules that undergo self-association in solution are widely encountered. As differences in surface properties, such as charge and hydrophobicity, between monomeric and polymeric forms, are very probable it should be possible to use the counter-current distribution technique in two-phase liquid systems for the study of self-association. The distribution behaviour of a self-associating solute has been simulated in order to establish the boundary conditions and limitations as well as potentials of the counter-current distribution technique as a tool for studying self-associations. The distributions have been calculated for a range of association constants, partition coefficients and initial solute concentration as well as for small zone and moving boundary counter-current distribution.
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