Abstract
Background: Leptadenia hastata (L. Hastata) is a plant used for various diseases in Nigeria. This study evaluated the protective effects of L. hastate on the haematological and biochemical alterations in adrenaline-induced hypertensive rats. Methods: Twenty-five rats were divided equally into five groups (A-E). Groups A-D were given 0.5 mg/kg adrenaline, groups A and B were treated with 100 and 200 mg/kg the extract of L. Hastata, respectively, while groups C and D were treated with 5 mg/kg amlodipine (standard control) and normal saline (untreated control), respectively. Group E were given distilled water (normal controls). The adrenaline was injected intraperitoneally while the extract was given orally once daily for seven days. Results: Treatment with 100 and 200 mg/kg of the extract significantly reduced the elevated serum albumin, ALP, ALT, AST, chloride, sodium and creatinine, cholesterol and LDL concentrations compared with the untreated hypertensive rats. The bicarbonate level, WBC and RBC counts, mean cell hemoglobin and packed cell value were higher in rats treated with the extract compared with the untreated hypertensive rats. The mean cell value, HDL, triglyceride, urea, potassium, total and direct bilirubin concentrations in experimental groups were not significantly different from those in the controls (P<0.05). Conclusion: Our results suggest that treatment of the hypertensive rats with the extract of L. Hastata protects against renal, hepatic and cardiac damages, thus it could be considered as a natural anti-hypertensive agent. Further studies are required to identify the bioactive constituents and the mechanism(s) of action.
Highlights
C ardiovascular diseases, such as hypertension, arteriosclerosis and heart disease, are prevalent in developed countries, with increasing numbers of people showing the associated symptoms [1]
Treatment with 100 and 200 mg/kg of the extract significantly reduced the elevated serum albumin, ALP, ALT, AST, chloride, sodium and creatinine, cholesterol and LDL concentrations compared with the untreated hypertensive rats
The bicarbonate level, White Blood Cells (WBC) and Red Blood Cells (RBC) counts, mean cell hemoglobin and packed cell value were higher in rats treated with the extract compared with the untreated hypertensive rats
Summary
C ardiovascular diseases, such as hypertension, arteriosclerosis and heart disease, are prevalent in developed countries, with increasing numbers of people showing the associated symptoms [1]. High blood pressure is a common disorder in developing countries, such as Nigeria, which if not effectively treated, results in a greatly increased probability of coronary thrombosis, stroke and renal failure [2]. Treatment of hypertension reduces cardiovascular risks, and this has been a major focus of campaigns aimed at reducing the associated morbidity and mortality [4]. Natural products from medicinal plants provide a large diversity of safe bioactive agents against some diseases [5]. Hastata) is a plant used for various diseases in Nigeria. Hastate on the haematological and biochemical alterations in adrenaline-induced hypertensive rats
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call