Abstract
Protective Role of Ficus carica Extract Against Hepato-Testicular Side Effects and Genotoxicity Induced by Cisplatin
Highlights
Plant products and their secondary metabolites are generally safer and cheaper compared to synthetic drugs and could be used for the treatment of many diseases
The total phenolic and total flavanoid contents in methanol extract were expressed as chemical equivalents of chlorogenic acid and rutin, respectively
The results demonstrated that Ficus carica at different doses alleviated the over expression of inducible nitric oxide synthase (iNOS) gene compared to cisplatin group especially with the doses 400 and 600 mg/kg (P0.001)
Summary
Plant products and their secondary metabolites are generally safer and cheaper compared to synthetic drugs and could be used for the treatment of many diseases. Ficus carica Linn (Moraceae) is an important plant in the genus Ficus and commonly referred to as “fig”. It is one of the first plants that were cultivated in the world. Ficus carica is an important genetic resource with high nutritional and economic values. It has been used in traditional medicine for the treatment of a wide range of ailments related to digestive, endocrine, reproductive and respiratory systems. It is used in the gastrointestinal tract, urinary tract infections and for inflammatoryrelated diseases and cancer. Some of the most interesting therapeutic activities include: immunosuppressive[3], antiinflammatory[4], hepatoprotective[5 ], hypoglycemic[6] and anticancer activities[7]
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