Abstract
The idiotypic–anti-idiotypic network seems to play an important role in the regulation of the autoimmune response. Coeliac disease (CD) is a gluten-dependent autoimmune disease associated with circulating anti-transglutaminase antibodies (anti-tTG), which are synthesized in the intestinal mucosa and are involved in the pathogenesis of CD. An idiotypic network may be involved in sequestering the anti-tTG to modulate both the clinical manifestation and the degree of the intestinal lesions. The anti-tTG belongs to the restricted family of VH5 limiting the number of idiotypes so that the CD can be used as a model for studying the role of idiotypic–anti-idiotypic network in autoimmune disorders.
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