Abstract
Protective immune responses to dengue virus infection and vaccines: perspectives from the field to the bench.
Highlights
A longitudinal study on human immune responses to wild-type dengue virus (DENV) infection describes how heterotypic immunity modulates disease, including evidence that cellular immunity contributes to protection [8]
Studies on humans and animal models, summarized by Petitdemange et al [9], find that antibody-dependent cell-mediated cytotoxicity (ADCC) and natural killer (NK) cells contribute to controlling early-stage viral infections
Monkeys inoculated with tetravalent Sanofi and Takeda live-attenuated chimeric vaccines revealed the same dominance of DENV 4 and DENV 2-driven immune responses and protection observed in humans, respectively
Summary
A longitudinal study on human immune responses to wild-type DENV infection describes how heterotypic immunity modulates disease, including evidence that cellular immunity contributes to protection [8]. Weiskopf and Sette show that CD8+ T cells contribute to protection against disease with second DENV infections by targeting epitopes on non-structural antigens [8]. In the Sanofi tetravalent chimeric vaccine, this T cell contribution may be missing as DENV non-structural proteins are not present in the vaccine, replaced by those of yellow fever [1,2,3].
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