Abstract
PURPOSEDisuse‐induced muscle atrophy and capillary regression in skeletal muscle are related to overexpression of oxidative stress caused mitochondrial dysfunction. The purpose of the present study was to identify the effect of loading combined with astaxanthin on capillary regression of the soleus muscle induced by hindlimb unloading.METHODSThirty‐five adult male rats were divided into control, hindlimb unloading (HU), HU+astaxanthin (Ax), HU+loading (Lo) and HU+Ax+Lo groups.RESULTSHU resulted in a decreased muscle mass and capillary regression. The loading attenuated the muscle atrophy, which increased the ROS and SOD‐1, resulting in a capillary regression. The combination of loading and astaxanthin attenuated the overexpression of oxidative stress. In addition, the combination increased the expression of e‐NOS, PGC‐1α and succinate dehydrogenase activity, reflecting a protective effect of mitochondrial function and the architecture of capillary network.CONCLUSIONLoading combined with astaxanthin is effective in preventing capillary regression in the soleus muscle induced by hindlimb unloading. Supported by Grants‐in‐Aid for Science Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology.
Published Version
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