Abstract
Hemidesmus indicus (L.) R. Br. var. pubescens (W. & A.) H k. f. was evaluated for hepatoprotective property against paracetamol induced hepatotoxicity in Wistar albino rats. In this study, methanol extract of the leaves of H. indicus var. pubescens at doses 200 and 400 mg/kg body weight were administered p.o. along with paracetamol at the dose 1 g/kg b.w for 7 days. . On the 8 th day, serum biochemical estimations were carried out to measure the serum levels of SGOT, SGPT, ALP, total proteins, albumin and total bilirubin. Histopathological examination of liver sections was also performed to study the extent of damage to hepatic parenchyma. Preliminary phytochemical screening of the extract was carried out to find out the presence of various phytoconstituents. HPTLC fingerprint profiles of the detected phytoconstituents were also obtained. Daily administration of paracetamol caused profound hepatic damage as evidenced by the significant elevation of liver transaminases, alkaline phosphatase, total bilirubin and triglycerides. Hepatotoxicity also caused a significant fall in serum levels of total proteins, albumin and high density lipoprotein. There was significant depletion of hepatic levels of glutathione. These biochemical aberrations were corrected in the animals pretreated with HILM 200 and 400 mg/kg. Phytochemical screening of the extract revealed the presence of vital phytoocnstituents in the extract which could have contributed to the hepatoprotective effect of the plant. The findings of the study prove that H. indicus var. pubescens possess significant hepatoprotective properties.
Published Version
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