Abstract
Abstract : We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologicallyprotected against cisplatin-induced acute renal failure (ARF) and CCl 4 -induced acute liver failure (ALF). In ARF model,0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine inmice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expressionof the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-α) in the kidney. In ALF model,0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice.Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-α in the liver.These results indicate that a MAS might have protective effects against ARF and ALF.Keywords : CCl 4 -induced acute liver failure, cisplatin-induced acute renal failure, mineral aqueous solution, silicon
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