Protective effect with vascular endothelium of Danhong injection on unstable angina after coronary intervention in patients

Abstract

Objective To observe the protective effects with vascular endothelium of Danhong injection for unstable angina (UA) after percutaneous coronary intervention in patients. Methods 180 patients with UA were randomly divided into two groups, and patients undergoing percutaneous coronary intervention (PCI) therapy.In addition, 90 cases in the control group were treated with conventional western medicine treatment, 90 cases in the observation group were treated with conventional western medicine treatment and Danhong injection therapy.The serum superoxide dismutase (SOD), malondialdehyde (MDA) and brachial artery flow-mediated endothelium-dependent vasodilation (FMD), von Willebrand factor (vWF), plasma nitric oxide (NO), endothelin-1 (ET-1) levels and other indicators before and after treatment were detected. Results The total effective rate of the observation group was 96.67%, which was significantly higher than 75.56% of the control group (χ2=9.23, P<0.05). The endothelial function parameters NO(73.66±11.58)μmol/L, ET-1(64.75±6.83)ng/L, vWF(114.58±16.24)%, FMD (6.54±0.88)% of the observation group after treatment were significantly improved than before treatment (t=8.04, 7.90, 8.44, 7.67, all P<0.05), which of the control group were (62.78±10.42)μmol/L, (92.31±8.67)ng/L, (152.64±18.75)%, (4.18±0.72)%, there were significant differences(t=6.78, 7.34, 7.70, 6.56, all P<0.05). The serum SOD (154.62±21.37)U/mL and MDA (4.18±0.79)nmol/L levels of the observation group were significantly improved than before treatment(t=7.58, 8.67, all P<0.05), which of the control group were (132.45±26.89)U/mL, (5.27±1.16)nmol/L, there were significant differences (t=7.22, 7.81, all P<0.05). Conclusion Danhong injection for the treatment of UA stasis syndrome can be widely promoted by reducing oxidative stress on vascular endothelial damage, and improving endothelial function in patients after PCI, has great clinical value. Key words: Danhong injection; Unstable angina; Percutaneous coronary intervention; Vascular endothelial function