Protective Effect of TNFRSF11A rs7239667 G > C Gene Polymorphism on Coronary Outcome of Kawasaki Disease in Southern Chinese Population.

Linyuan Zhang,Kun Lin,Lei Pi,Yufen Xu,Hongyan Yu,Zhiyong Jiang,Lanyan Fu,Xiaoqiong Gu,Bing Wei,Jinqing Li,Yishuai Wang,Di Che,Hanran Mai

doi:10.3389/fgene.2021.691282

Abstract

BackgroundThe main symptoms of Kawasaki disease (KD) are inflammatory vasculitis characterized by fever lasting 1–2 weeks, failure to respond to antibiotic treatment, conjunctivitis, redness of the lips and mouth, strawberry tongue, and painless enlargement of the neck lymph nodes. Studies have been shown that tumor necrosis factor (TNF) and TNF receptor family members are abnormally expressed in the acute phase of Kawasaki disease, also revealing that these two play a significant role in the pathogenesis of KD. The purpose of our study is to determine the relationship between TNFRSF11A rs7239667 and the pathogenesis of KD and Coronary artery lesions in KD.Methods and ResultsIn this study, TNFRSF11A (rs7239667) genotyping was performed in 1396 patients with KD and 1673 healthy controls. Our results showed that G > C polymorphism of TNFRSF11A (rs7239667) was not associated with KD susceptibility. In addition, the patients with KD were divided into CAA and NCAA groups according to whether they had coronary artery aneurysm (CAA) or not, and the TNFRSF11A rs7239667 genotyping was performed in the two groups. After gender and age calibration, We found that genotype CC of TNFRSF11A may be a protective factor in KD coronary artery damage (adjusted OR = 0.69 95% CI = 0.49–0.99 P = 0.0429) and is more significant in children with KD ≤ 60 months (adjusted OR = 0.49 95% CI = 0.49–0.93 P = 0.0173).ConclusionOur study suggests that TNFRSF11A rs7239667 G > C polymorphism maybe play a protective gene role for the severity of KD coronary artery injury and is related to age, which has not been previously revealed.

Highlights

Kawasaki disease is an immune angioinflammatory disease characterized by a fever that persists for 1–2 weeks, conjunctivitis, redness of the lips and mouth, enlarged non-suppurative lymph nodes in the neck, and peeling of the hands and feet (Kato et al, 1975; Newburger et al, 2004)
We aimed to explore the association between TNFRSF11A gene polymorphism and genetic susceptibility to Kawasaki disease (KD) and Coronary artery lesion (CAL) in southern Chinese population
To investigate the effect of TNFRSF11A gene polymorphism on the severity of coronary complications associated with KD, we enrolled 1396 patients with KD diagnosed at Guangzhou Women and Children’s Medical Center

Summary

Introduction

Kawasaki disease is an immune angioinflammatory disease characterized by a fever that persists for 1–2 weeks, conjunctivitis, redness of the lips and mouth, enlarged non-suppurative lymph nodes in the neck, and peeling of the hands and feet (Kato et al, 1975; Newburger et al, 2004). Intravenous gamma globulin is often used for the anti-inflammatory treatment of acute phase of KD in clinic (Gupta et al, 2001; Kumrah et al, 2020). At present, it has been more than 50 years since the first diagnosed KD case, and researches on its etiology and pathogenesis continue continuously, but its etiology and pathogenesis are still an unsolved mystery (Tacke et al, 2012). The purpose of our study is to determine the relationship between TNFRSF11A rs7239667 and the pathogenesis of KD and Coronary artery lesions in KD

Objectives

Methods

Results