Abstract
Members of the tumor necrosis factor (TNF) and TNF receptor (TNFR) families mediate many important functions in the mammalian organism. Ligand-receptor interactions result in signals promoting cell activation, proliferation, inhibition or death. Advances in gene targeting technology continue to uncover biological functions of these molecules in vivo. The review discusses the current state of the field with specific emphasis on the role of TNF and TNFR family members in host defense and their contrasting roles in cancer development and progression. Other features, such as defects in lymphopoiesis, lymphoid organogenesis, and epidermal development are also briefly reviewed.
Published Version
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