Abstract
BackgroundThe purpose of this study was to investigate the effect of Suxiao Jiuxin Pill (SX), a traditional Chinese medicine, on acute myocardial ischemia induced by coronary occlusion in anesthetized dogs.MethodsAcute myocardial ischemia model was established by ligating the left anterior descending artery to reduce flow by 90 %. Adult mongrel dogs were randomly divided into six groups: model, SX high dose, SX middle dose, SX low dose, Isosorbide dinitrate (ISD) and Sham groups. Adult mongrel dogs were anesthetized and instrumented for measurements of heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricular dP/dt, coronary blood flow (CBF), myocardial blood flow (MBF), coronary vascular resistance (CVR), and epicardial electrocardiogram (EECG). After administration with SX, changes in hemodynamics were recorded. Serum enzymes and blood gas analysis were also detected.ResultsSX has a dose-dependent effect on the reduction of infarct size. Besides, SX exerted a notable inhibition on the elevation of serum creatine kinase MB (CK-MB), lactate dehydrogenase (LDH), malondialdehyde (MDA), and elevation in the superoxide dismutase (SOD) activity. SX also showed a capacity to recover myocardial function by significantly reducing MAP, CVR, LVSP, left ventricular systolic pressure (LVEDP), systolic blood pressure (SBP), diastolic blood pressure (SDP), and increasing CBF and myocardial blood flow (MBF). In addition, SX high dose group markedly reduced total mV of ST segment elevation (Σ-ST), total number of sites with this degree of ST segment elevation (N-ST) and oxygen extraction ratio (O2 Extr).ConclusionSX can improve hemodynamic and myocardial oxygen metabolism, reduce the degree and scope of myocardial ischemia, and hence exert notable anti-anginal ischaemic effect.
Highlights
The purpose of this study was to investigate the effect of Suxiao Jiuxin Pill (SX), a traditional Chinese medicine, on acute myocardial ischemia induced by coronary occlusion in anesthetized dogs
44 healthy dogs were selected by weight and ECG, and randomly divided into six groups based on weight: model, SX high dose (SX, 25.60 mg/ml/kg), SX middle dose (SX, 12.80 mg/ml/kg), SX low does (SX, 6.40 mg/ml/kg,) and Isosorbide dinitrate (ISD, 0.80 mg/ml/kg), and Sham with 7, 7, 9, 7, 6, and 8 animals in each groups respectively
Post-ischemia myocardium was associated with a 17.84 ± 2.83 % infarct size which was consistently reduced by increasing concentrations of SX to 7.33 ± 4.39 % (P < 0.01, 6.40 mg/kg SX), 6.03 ± 3.13 % (P
Summary
The purpose of this study was to investigate the effect of Suxiao Jiuxin Pill (SX), a traditional Chinese medicine, on acute myocardial ischemia induced by coronary occlusion in anesthetized dogs. Modern medicine has improved dramatically as the treatment of cardiovascular disease. SX is one of the most efficacious Chinese patent medicines for the treatment of cardiocerebral vascular diseases. It was developed on years of clinical experience by old Chinese medicine experts – Chenggui Zhang in the 1980s, and manufactured by the Sixth Chinese Drugs Factory of Tianjin Zhongxin Pharmaceutical Co., Ltd., Tianjin, China [7]. It has been used for the treatment of coronary heart disease, angina pectoris, myocardial
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