Abstract
The purpose of this study was to investigate possible beneficial effects of Panax ginseng (PG) on carbon tetrachloride (CCl 4)-induced acute hepatotoxicity in rats. CCl 4 challenge elevated serum enzyme activities of liver and some biochemical parameters, but these effects were prevented by the pretreatment of rats with PG. Histologically, a great amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver of CCl 4 group. Also, CD68 + and caspase-3 staining cells were diffused in both lobular and portal areas. However, PG pretreatment had a little influence on the number of caspase-3 immunpositive staining cells in the liver, but CD68 + staining areas were significantly decreased in the PG + CCl 4 when compared to CCl 4 group. We conclude that PG treatment may play a protective role by enhancing liver enzyme activities and recovering biochemical parameters, and improving the changes in histological structure against CCl 4-induced liver damages in rats.
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