Protective effect of micro needle array drug delivery technology on the blood vessel of arteriovenous fistula

Abstract

Objective To investigate the protective effect of mucopolysaccharide polysulfate cream(MPC) and micro needle array drug delivery technologarray(MNADDT) on the blood vessel of arteriovenous fistula. Methods Eighty cases maintenance hemodialysis patients with autogenous arteriovenous fistula were randomly divided into control group(with the treatment of MPC) and study group(with the treatment of MPC plus MNADDT), 40 patients in each group.Both groups were studied for the duration of 12 months.The vascular complications of puncture pain sense, puncture failure times, phlebitis, hardening of the arteries, internal fistula stenosis or embolism, pseudoaneurysm, swollen hands comprehensive syndrome of two groups were observed, and the changes of arteriovenous fistula blood flow, blood vessel diameter by Doppler ultrasound were observed in the two groups for 12 months. Results (1)The incidence of puncture pain(2.71±0.11 vs.2.76±0.14, t=2.21, P<0.05), puncture failure times(38 times vs.73 times, χ2=11.425, P<0.05), phlebitis(2 cases vs.8 cases, χ2=4.341, P<0.05) and blood vessel sclerosis(2 cases vs.9 cases, χ2=5.446, P<0.05) of the treatment group were significantly lower than that of the control group during the study(P<0.05). (2)Blood flow of arteriovenous fistulain of control group before and after treatment were (859.7±148.3) ml/min and ( 946.5±169.2) ml/min respectively, and the difference was significant(t=2.356, P<0.05). While blood flow of arteriovenous fistulain, cephalic vein diameter, head of venous flow velocity of study group before and after treatment were (824.6±171.5 ) ml/min and ( 1 218.1±241.9) ml/min, (5.59±0.74) mm and (6.02±0.57) mm, (94.23±27.35) cm/s and (115.85±36.63) cm/s, respectively, and the differences were significant(t=8.212, 2.382, 2.877, P<0.05), there were no significantly changes in the above indexes in the study group after treatment(t=5.3612, 2.152, 2.281, P<0.05). Conclusion MPC plus MNADDT can reduce the vascular complications of arteriovenous fistula, improve blood vessel diameter and increase blood flow. Key words: Hemodialysis; Arteriovenous fistula; Complication; Micro needle array administration; Doppler ultrasound