Abstract
Carbendazim is a broad spectrum carbamate fungicide used in the control of various fungal pathogens. The present work studied the effect of carbendazim on the liver of albino rats and the possible protective role of Ginko biloba extract (EGB). Liver of carbendazim-treated animals showed histopathological and histochemical alterations. The histopathological changes include hepatic tissue impairment, cytoplasmic vacuolization of the hepatocytes, and congestion of blood vessels, leucocytic infiltrations and fatty infiltration. Histochemical results showed reduction of carbohydrates and total proteins in hepatic tissues. Moreover, liver function enzymes (ALT, AST) were elevated in sera of carbendazim-treated animals. Coadministration of EGB with Carbendazim improved the hisological and histochemical changes observed in animals treated with carbendazim. In addition, EGB treatment leads to a significant decrease in ALT and AST. According to the present results, it is concluded that EGB can improve the hepatotoxicity of carbendazim and this effect may be attributed to antioxidant properties of Ginko biloba extract.
Highlights
Fungicides are used to protect seeds, fruits and vegetables during storage or are applied directly to ornamental plants, trees, field crops, cereals and turf grasses
According to the present results, it is concluded that EGB can improve the hepatotoxicity of carbendazim and this effect may be attributed to antioxidant properties of Ginko biloba extract
The present results showed that carbendazim caused many histopathological alterations in the liver of rats
Summary
Fungicides are used to protect seeds, fruits and vegetables during storage or are applied directly to ornamental plants, trees, field crops, cereals and turf grasses. Carbendazim (methyl-2-benzimidazole carbamate), is a systemic benzimidazole fungicide that plays a very important role in plant disease control. It is used as a preservative in paint, papermaking and in the leather industry and further used as a preservative of fruits [5]. Long-term exposure to carbendazim resulted in the decreased survival rate, body weight, and hematological, biochemical, and histopathological alterations in adrenal, thyroid, liver, and testis [6,7]. It can disrupt the development of sperm and damage testicular development in rats [8]. Muthuviveganandavel et al [9] reported that carbendazim induced biochemical and histopathological alterations in liver of rats
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