Abstract
This study was carried out to explore the protective effect of L-3-nbutylphthalide (NBP) on the brain of ethanol dependence rats. With the administration of different dosage of NBP, the variation of withdrawal scores, hydrogen sulfide (H2S) contents, cystathionine β-synthase (CBS) activities and expression N-methyl-D-aspartate (NMDA) receptor 2B subunit (NR2B) in the hippocampus tissue of ethanol dependent rats were discussed. Results showed that most significant difference in withdrawal symptom score, H2S content, CBS activity and the expression of NR2B mRNA between normal and ethanol dependence model group rats (P 0.05). However, withdrawal symptom score, H2S content, CBS activity and NR2B mRNA expression in both middle and high dose NBP group rats were much lower than those of experiment control group (P<0.05). With increasing concentrations of NBP, it could reduce withdrawal symptoms of ethanol dependence rats to different extent. The alleviation of ethanol dependence symptoms mediated by NBP may be related to down-regulation in NR2B mRNA expression. Key words: Ethanol dependence, L-3-nbutylphthalide, hydrogen sulfide (H2S), cystathionine β-synthase activity, N-methyl-D-aspartate (NMDA) receptor 2B subunit (NR2B).
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