Abstract
<p>The aim of this study was to evaluate the protective effects of hydroethanolic extracts of <em>S.</em> <em>scabrum</em> and <em>C. verticillata</em> against cyclophosphamide induced toxicity. In this light, female albino wistar rats were treated by intraperitoneal administration of 100 mg/kg BW of cyclophosphamide or distilled water every other day for 7 days associated with oral gavage using hydroethanolic extract of <em>C. verticillata</em>/<em>S. scabrum</em> at a dose of 200 or 400 mg/kg BW or not every day for the same 7 days. On the 8th day, blood and organs (liver, heart and kidney) were collected for analyses of toxicity-related and oxidative stress markers. Cyclophosphamide treatment induced significant toxicity as shown by liver enzymes, urea and creatinine levels. The administration of extracts helped reduce the levels of these markers. The antioxidant effect of these extracts also helped or not to ameliorate oxidative stress markers (MDA, NO, hydroperoxides, catalase, thiols, GPx) depending on the extract and on the dose administered. These results suggest that administration of hydroethanolic extracts of <em>S.</em> <em>scabrum</em> and <em>C. verticillata</em> can help prevent or reduce toxicity that is brought about by treatment with cyclophosphamide due to their ability to upregulate antioxidant mechanisms.</p>
Highlights
Chemotherapy has been used for many years and is still today, one of the most common treatments for cancer
Female albino wistar rats were treated by intraperitoneal administration of 100 mg/kg BW of cyclophosphamide or distilled water every other day for 7 days associated with oral gavage using hydroethanolic extract of C. verticillata/S. scabrum at a dose of 200 or 400 mg/kg BW or not every day for the same 7 days
The antioxidant effect of these extracts helped or not to ameliorate oxidative stress markers (MDA, Nitric Oxide (NO), hydroperoxides, catalase, thiols, GPx) depending on the extract and on the dose administered. These results suggest that administration of hydroethanolic extracts of S. scabrum and C. verticillata can help prevent or reduce toxicity that is brought about by treatment with cyclophosphamide due to their ability to upregulate antioxidant mechanisms
Summary
Chemotherapy has been used for many years and is still today, one of the most common treatments for cancer. Chemotherapeutic drugs act by interfering with the growth of cancer cells (cytoxicity). Their toxicity is not always limited to these cells and extended to normal cells leading to various types of disorders in the organism that receives the treatment. An example to such chemotherapeutic agents is cyclophosphamide. Revnic, & Botea, 2005; Selvakumar, Prahalathan, & Varalakshmi, 2006)
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